Intraoperative specimen handling is a critical part of patient care during surgical procedures requiring clear communication and competency among all surgical team members. Specimen management includes collection of specimens, test ordering, labeling, proper containment and storage, tracking, transporting, lab processing and quality monitoring and reporting. Efficient and comprehensive electronic health record system is a key component to specimen management by providing access to clear documentation and applicable orderable sources and tests within the perioperative application. A project group was assembled and gathered information of what functions effectively and what were challenges, barriers and improvements that were needed. Expanding lab tracking maintained the chain of custody for the specimens. Education was developed and quality reports were enhanced to allow for quick follow up in real time by perioperative and laboratory leaders. Surgeons were also engaged thru Governance committees to share enhancements and clear communication expectation regarding specimen labeling and testing requested. Multiple teams participated in this project to improve the specimen management process and ensuring accurate results for improved safe patient care. This project demonstrated significant improvement in patient safety events and reduction in ordering errors